Concentration‐QTc modeling of sitravatinib in patients with advanced solid malignancies

Concentration‐QTc modeling of sitravatinib in patients with advanced solid malignancies

Abstract Sitravatinib (MGCD516) is an orally available, small molecule, tyrosine kinase inhibitor that has been evaluated in patients with advanced solid tumors. Concentration‐corrected QT interval (QTc; C‐QTc) modeling was undertaken, using 767 matched concentration‐ECG observations from 187 patien...

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Main Authors: Adam Dickinson (Author), Yong Liu (Author), Artem Uvarov (Author), Thomas Peyret (Author), J. F. Marier (Author), Curtis Chin (Author), Jonathan Q. Tran (Author)
Format: Book
Published: Wiley, 2024-05-01T00:00:00Z.
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