Concentration‐QTc modeling of sitravatinib in patients with advanced solid malignancies

• Main Authors: Adam Dickinson (Author), Yong Liu (Author), Artem Uvarov (Author), Thomas Peyret (Author), J. F. Marier (Author), Curtis Chin (Author), Jonathan Q. Tran (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sitravatinib (MGCD516) is an orally available, small molecule, tyrosine kinase inhibitor that has been evaluated in patients with advanced solid tumors. Concentration‐corrected QT interval (QTc; C‐QTc) modeling was undertaken, using 767 matched concentration‐ECG observations from 187 patien...