Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease

• Main Authors: Bo Qin (Author), Gregory B. Craven (Author), Pengjiao Hou (Author), Julian Chesti (Author), Xinran Lu (Author), Emma S. Child (Author), Rhodri M.L. Morgan (Author), Wenchao Niu (Author), Lina Zhao (Author), Alan Armstrong (Author), David J. Mann (Author), Sheng Cui (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional proteins. Many of these proteases exhibit a similar fold and contain an essential catalytic cysteine, offering the opportunity to inhibit these enzymes with electrophilic small molecu...