Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

• Main Authors: Juha J. Hulmi (Author), Tuuli A. Nissinen (Author), Markus Räsänen (Author), Joni Degerman (Author), Juulia H. Lautaoja (Author), Karthik Amudhala Hemanthakumar (Author), Janne T. Backman (Author), Olli Ritvos (Author), Mika Silvennoinen (Author), Riikka Kivelä (Author)
• Format: Book
• Published: Wiley, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of life. Doxorubicin (DOX) is an effective cytostatic agent, which unfortunately has toxic effects on many healthy tissues. Blocking of act...