Semaglutide as a Possible Calmodulin Binder: Ligand-Based Computational Analyses and Relevance to Its Associated Reward and Appetitive Behaviour Actions

• Main Authors: Giuseppe Floresta (Author), Davide Arillotta (Author), Valeria Catalani (Author), Gabriele Duccio Papanti Pelletier (Author), John Martin Corkery (Author), Amira Guirguis (Author), Fabrizio Schifano (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention as a therapeutic agent for type 2 diabetes mellitus and obesity. Despite its clinical success, the precise mechanisms underlying its pharmacological effects remain incompletely understood. In this stud...