Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome

• Main Authors: Sachiko Nakakubo (Author), Yasuyoshi Hiramatsu (Author), Takeru Goto (Author), Syuhei Kimura (Author), Masashi Narugami (Author), Midori Nakajima (Author), Yuki Ueda (Author), Hideaki Shiraishi (Author), Atsushi Manabe (Author), Dishary Sharmin (Author), James M. Cook (Author), Kiyoshi Egawa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na channel. Pre-synaptic inhibitory dysfunction is regard...