Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254)

• Hlavní autoři: Konstantinos Stamatopoulos (Autor), Paola Ferrini (Autor), Dung Nguyen (Autor), Ying Zhang (Autor), James M. Butler (Autor), Jon Hall (Autor), Nena Mistry (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2023-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described. The PBBM model was developed, qualified and verified using clinical data of an immediate relea...