Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors

• Main Authors: Bo Yang (Author), Yanni Quan (Author), Wuli Zhao (Author), Yingjie Ji (Author), Xiaotang Yang (Author), Jianrui Li (Author), Yi Li (Author), Xiujun Liu (Author), Ying Wang (Author), Yanping Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To explore the potential use of CDK inhibitors in pancreatic ductal adenocarcinoma (PDAC) therapy, a series of novel 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives was designed, synthesised, and investigated for inhibition on both CDK kinase activity and cellular proliferation of...