Genetic and environmental circadian disruption induce weight gain through changes in the gut microbiome

• Main Authors: Baraa Altaha (Author), Marjolein Heddes (Author), Violetta Pilorz (Author), Yunhui Niu (Author), Elizaveta Gorbunova (Author), Michael Gigl (Author), Karin Kleigrewe (Author), Henrik Oster (Author), Dirk Haller (Author), Silke Kiessling (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Internal clocks time behavior and physiology, including the gut microbiome, in a circadian (∼24 h) manner. Mismatch between internal and external time, e.g. during shift work, disrupts circadian system coordination promoting the development of obesity and type 2 diabetes (T2D). Conversely...