Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction

• Main Authors: Laura Oggianu (Author), Alice B. Ke (Author), Manoranjenni Chetty (Author), Rossella Picollo (Author), Vanessa Petrucci (Author), Fabrizio Calisti (Author), Fabio Garofolo (Author), Serena Tongiani (Author)
• Format: Book
• Published: Wiley, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a paucity of clinical trials for the treatment of pediatric insomnia. This study was designed to predict the doses of trazodone to guide dosing in a clinical trial for pediatric insomnia using physiologically‐based pharmacokinetic (PBPK) modeling. Data on the pharmacokinetics of trazodone i...