IL-10 modified mRNA monotherapy prolongs survival after composite facial allografting through the induction of mixed chimerism

• Main Authors: Ana Elena Aviña (Author), Dante De Paz (Author), Shu-Chun Huang (Author), Kuan-Hung Chen (Author), Yun-Ching Chang (Author), Chin-Ming Lee (Author), Chia-Hsien Lin (Author), Fu-Chan Wei (Author), Aline Yen Ling Wang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascularized composite allotransplantation has great potential in face transplantation by supporting functional restoration following tissue grafting. However, the need for lifelong administration of immunosuppressive drugs still limits its wide use. Modified mRNA (modRNA) technology provides an eff...