Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse

• Автори: Sina M. Coldewey (Автор), Mara Rogazzo (Автор), Massimo Collino (Автор), Nimesh S. A. Patel (Автор), Christoph Thiemermann (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2013-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

SUMMARY Nuclear factor κB (NF-κB) plays a pivotal role in sepsis. Activation of NF-κB is initiated by the signal-induced ubiquitylation and subsequent degradation of inhibitors of kappa B (IκBs) primarily via activation of the IκB kinase (IKK). This study was designed to investigate the effects of I...