Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse

• Main Authors: Sina M. Coldewey (Author), Mara Rogazzo (Author), Massimo Collino (Author), Nimesh S. A. Patel (Author), Christoph Thiemermann (Author)
• Format: Book
• Published: The Company of Biologists, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Nuclear factor κB (NF-κB) plays a pivotal role in sepsis. Activation of NF-κB is initiated by the signal-induced ubiquitylation and subsequent degradation of inhibitors of kappa B (IκBs) primarily via activation of the IκB kinase (IKK). This study was designed to investigate the effects of I...