Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats

• Main Authors: Deborah Dhuyvetter (Author), Fetene Tekle (Author), Maxim Nazarov (Author), Rob J. Vreeken (Author), Herman Borghys (Author), Frederik Rombouts (Author), Ilse Lenaerts (Author), Astrid Bottelbergs (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery. However, despite the body of evidence for IN drug de...