Insights into the molecular mechanisms underlying mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms

• Main Authors: Lin-Hua eJiang (Author), jocelyn eBaldwin (Author), Sébastien eRoger (Author), Stephen eBaldwin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mammalian P2X7 receptors (P2X7Rs), a member of the ionotropic P2X receptor family with distinctive functional properties, play an important part in mediating extracellular ATP signaling in health and disease. A clear delineation of the molecular mechanisms underlying the key receptor properties,...