Disruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells

• Asıl Yazarlar: Diana Tavares-Valente (Yazar), Bárbara Sousa (Yazar), Fernando Schmitt (Yazar), Fátima Baltazar (Yazar), Odília Queirós (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism. This phenotype is supported by increased activity of pH regulators like ATPases, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs) and sodium-proton exchangers (NHEs) that induce an acidic tu...