Association of catechol-O-methyltransferase gene polymorphisms with treatment response and levodopa-induced complications in Parkinson's disease: A summary of current knowledge

• Main Authors: Radojević Branislava S. (Author), Jančić Ivan (Author), Savić Miroslav M. (Author), Kostić Vladimir S. (Author), Dragašević-Mišković Nataša T. (Author)
• Format: Book
• Published: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes in the degradation of catecholamines and levodopa. Genetic variants of the COMT gene may affect COMT enzyme activity. The most examined COMT gene polymorphism is the nonsynonymous single nucleotide polymorphism (SNP) in exon 4 (Val10...