Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats

• Autors principals: Kritsakorn Rayasilp (Autor), Piyanuch Wonganan (Autor), Pajaree Chariyavilaskul (Autor), Nuntaporn Prompila (Autor), Varumporn Sukkummee (Autor), Supeecha Wittayalertpanya (Autor)
• Format: Llibre
• Publicat: Tabriz University of Medical Sciences, 2019-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Background: Food-drug interaction can decrease drug effectiveness or increase risk of drug toxicity. Simvastatin is widely used for treatment of hypercholesterolemia and hypertriglyceridemia. Therefore, this study aimed to investigate the effects of pomelo juice on the pharmacokinetics of simvastati...