SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

• Main Authors: Shuang Cui (Author), Huijian Hu (Author), An Chen (Author), Ming Cui (Author), Xiaojie Pan (Author), Pengfei Zhang (Author), Guangji Wang (Author), Hong Wang (Author), Haiping Hao (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show limited clinical benefits, without a clear mechanism. Here, we reveal that acetylation initiates and orchestrates FXR nucleocytoplasmic shuttling and th...