Targeting tumor endothelial hyperglycolysis enhances immunotherapy through remodeling tumor microenvironment

• Main Authors: Yunlong Shan (Author), Qi Ni (Author), Qixiang Zhang (Author), Mengying Zhang (Author), Bin Wei (Author), Lingge Cheng (Author), Chongjin Zhong (Author), Xinyu Wang (Author), Qingqing Wang (Author), Jiali Liu (Author), Jingwei Zhang (Author), Jingjing Wu (Author), Guangji Wang (Author), Fang Zhou (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular abnormality is a hallmark of most solid tumors and facilitates immune evasion. Targeting the abnormal metabolism of tumor endothelial cells (TECs) may provide an opportunity to improve the outcome of immunotherapy. Here, in comparison to vascular endothelial cells from adjacent peritumoral...