AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo

• Autori principali: Chunli Zhao (Autore), Zijing Yang (Autore), Zhongrui Chen (Autore), Wenqi Liang (Autore), Shusheng Gong (Autore), Zhengde Du (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2022-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellular metabolism. Both the UCP2 and ROS are increased in cochleae in age-r...