Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes

• Main Authors: Francisco Barajas-Olmos (Author), Federico Centeno-Cruz (Author), Carlos Zerrweck (Author), Iván Imaz-Rosshandler (Author), Angélica Martínez-Hernández (Author), Emilio J. Cordova (Author), Claudia Rangel-Escareño (Author), Faustino Gálvez (Author), Armando Castillo (Author), Hernán Maydón (Author), Francisco Campos (Author), Diana Gabriela Maldonado-Pintado (Author), Lorena Orozco (Author)
• Format: Book
• Published: BMC, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Obesity is a well-recognized risk factor for insulin resistance and type 2 diabetes (T2D), although the precise mechanisms underlying the relationship remain unknown. In this study we identified alterations of DNA methylation influencing T2D pathogenesis, in subcutaneous and visc...