Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-<span style="font-variant: small-caps">D</span>-mannitol Analogs

• Main Authors: Natasha Rana (Author), Marwa A. Aziz (Author), Ahmed K. Oraby (Author), Melinda Wuest (Author), Jennifer Dufour (Author), Khaled A. M. Abouzid (Author), Frank Wuest (Author), F. G. West (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deregulation and changes in energy metabolism are emergent and important biomarkers of cancer cells. The uptake of hexoses in cancer cells is mediated by a family of facilitative hexose membrane-transporter proteins known as Glucose Transporters (GLUTs). In the clinic, numerous breast cancers do not...