Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

• Main Authors: Cheng-Yang Wu (Author), Shih-Chia Tso (Author), Jacinta L. Chuang (Author), Wen-Jun Gui (Author), Mingliang Lou (Author), Gaurav Sharma (Author), Chalermchai Khemtong (Author), Xiangbing Qi (Author), R. Max Wynn (Author), David T. Chuang (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mitochondrial pyruvate dehydrogenase kinases 1-4 (PDKs1-4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDKs play a pivotal role in maintaining energy homeostasis and contribute to metabolic flexibility by attenuating PDC activity...