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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

Objective: Mitochondrial pyruvate dehydrogenase kinases 1-4 (PDKs1-4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDKs play a pivotal role in maintaining energy homeostasis and contribute to metabolic flexibility by attenuating PDC activity...

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Main Authors:	Cheng-Yang Wu (Author), Shih-Chia Tso (Author), Jacinta L. Chuang (Author), Wen-Jun Gui (Author), Mingliang Lou (Author), Gaurav Sharma (Author), Chalermchai Khemtong (Author), Xiangbing Qi (Author), R. Max Wynn (Author), David T. Chuang (Author)
Format:	Book
Published:	Elsevier, 2018-06-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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