Use of hydrophilic and hydrophobic polymers for the development of controlled release tizanidine matrix tablets

• Main Authors: Tariq Ali (Author), Muhammad Harris Shoaib (Author), Rabia Ismail Yousuf (Author), Sabahat Jabeen (Author), Iyad Naeem Muhammad (Author), Asfia Tariq (Author)
• Format: Book
• Published: Universidade de São Paulo, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the present study was to develop tizanidine controlled release matrix. Formulations were designed using central composite method with the help of design expert version 7.0 software. Avicel pH 101 in the range of 14-50% was used as a filler, while HPMC K4M and K100M in the range of 25-55%,...