YH12852, a Potent and Selective Receptor Agonist of 5‐hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation

• Main Authors: Hyun A. Lee (Author), Seol Ju Moon (Author), Hyounggyoon Yoo (Author), Mi Kyung Kim (Author), Seong Bok Jang (Author), Seoungoh Lee (Author), Sohee Kim (Author), Howard Lee (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastrointestinal (GI) motility disorders are common, decreases quality of life, and imposes a substantial economic burden. YH12852 is a novel agonist of 5‐hydroxytryptamine for the treatment of GI motility disorders. This phase I/IIa study assessed the tolerability, pharmacodynamic (PD) and pharmaco...