Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

• Main Authors: Manuela Curcio (Author), Giuseppe Cirillo (Author), Paola Tucci (Author), Annafranca Farfalla (Author), Emilia Bevacqua (Author), Orazio Vittorio (Author), Francesca Iemma (Author), Fiore Pasquale Nicoletta (Author)
• Format: Book
• Published: MDPI AG, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the aim to effectively deliver methotrexate (MTX) to breast cancer cells, we designed a nanocarrier system (DC) derived from the self-assembly of a dextran-curcumin conjugate prepared via enzyme chemistry with immobilized laccase acting as a solid biocatalyst. Nanoparticles consisted of homogen...