Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats

• Main Authors: Phanit Songvut (Author), Watanyoo Nakareangrit (Author), Wanida Cholpraipimolrat (Author), Jackapun Kwangjai (Author), Luksamee Worasuttayangkurn (Author), Piyajit Watcharasit (Author), Jutamaad Satayavivad (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThe available in vitro evidences suggest the inherent instability and interconvertibility of [6]-gingerol and [6]-shogaol. However, limited data on their in vivo interconversion hinder understanding of their influence on the pharmacokinetic profiles.PurposeThis study presents the first com...