Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta1-42 in mice

• Main Authors: Ridho Islamie (Author), Su Lwin Lwin Myint (Author), Tissana Rojanaratha (Author), Garnpimol Ritthidej (Author), Oraphan Wanakhachornkrai (Author), Onsurang Wattanathamsan (Author), Ratchanee Rodsiri (Author)
• 格式: 圖書
• 出版: BMC, 2023-08-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Background Amyloid-β1-42 (Aβ1-42) plays an essential role in the development of the early stage of Alzheimer's disease (AD). Asiatic acid (AA), an active compound in Centella asiatica L, exhibit neuroprotective properties in previous studies. Due to its low bioavailability, the nose-to...