Comparison of Toxicity and Toxicokinetics/Pharmacokinetics of an α1L-Adrenoceptor Agonist in Rats and Rhesus Monkeys

• Main Authors: Takehisa Matsumaru (Author), Reiko Sugiura (Author), Kenji Sakai (Author), Takashi Igarashi (Author), Takayoshi Kuno (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have investigated the toxicity of an α1L-adrenoceptor agonist, ESR 1150 CL, and compared the toxicokinetics and pharmacokinetics in rats and monkeys. In rats, this compound induced death with remarkable sacculated aneurysms of the aorta in groups given more than 3mg/kg per day in a 4-week repeate...