Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonis...

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Main Authors: Thomas J. Cirino (Author), Shainnel O. Eans (Author), Jessica M. Medina (Author), Lisa L. Wilson (Author), Marco Mottinelli (Author), Sebastiano Intagliata (Author), Christopher R. McCurdy (Author), Jay P. McLaughlin (Author)
Format: Book
Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
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3rd Floor Main Library

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