Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

• Asıl Yazarlar: Thomas J. Cirino (Yazar), Shainnel O. Eans (Yazar), Jessica M. Medina (Yazar), Lisa L. Wilson (Yazar), Marco Mottinelli (Yazar), Sebastiano Intagliata (Yazar), Christopher R. McCurdy (Yazar), Jay P. McLaughlin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonis...