Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

• Main Authors: Thomas J. Cirino (Author), Shainnel O. Eans (Author), Jessica M. Medina (Author), Lisa L. Wilson (Author), Marco Mottinelli (Author), Sebastiano Intagliata (Author), Christopher R. McCurdy (Author), Jay P. McLaughlin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonis...