Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

• Hoofdauteurs: Thomas J. Cirino (Auteur), Shainnel O. Eans (Auteur), Jessica M. Medina (Auteur), Lisa L. Wilson (Auteur), Marco Mottinelli (Auteur), Sebastiano Intagliata (Auteur), Christopher R. McCurdy (Auteur), Jay P. McLaughlin (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonis...