KIT exon 11 and PDGFRA exon 18 gene mutations in gastric GIST: proposal of a short panel for predicting therapeutic response

• Үндсэн зохиолчид: Denise Barcelos (Зохиогч), Ricardo Artigiani Neto (Зохиогч), Leonardo Cardili (Зохиогч), Mariana Fernandes (Зохиогч), Fernando Cintra Lopes Carapeto (Зохиогч), Andréia Neves Comodo (Зохиогч), Karina Funabashi (Зохиогч), Edna Sadayo Miazato Iwamura (Зохиогч)
• Формат: Ном
• Хэвлэсэн: BMC, 2018-11-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Background GIST is the most common mesenchymal tumor of gastrointestinal tract and is more frequent in stomach. Its main mutations affect KIT and PDGFRA genes. Full genetic analysis panels are currently used to study mutations in GIST and other tumors. Considering that in gastric GIST KIT g...