KIT exon 11 and PDGFRA exon 18 gene mutations in gastric GIST: proposal of a short panel for predicting therapeutic response

• Main Authors: Denise Barcelos (Author), Ricardo Artigiani Neto (Author), Leonardo Cardili (Author), Mariana Fernandes (Author), Fernando Cintra Lopes Carapeto (Author), Andréia Neves Comodo (Author), Karina Funabashi (Author), Edna Sadayo Miazato Iwamura (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background GIST is the most common mesenchymal tumor of gastrointestinal tract and is more frequent in stomach. Its main mutations affect KIT and PDGFRA genes. Full genetic analysis panels are currently used to study mutations in GIST and other tumors. Considering that in gastric GIST KIT g...