Synthesis, Characterization, and Intrinsic Dissolution Studies of Drug-Drug Eutectic Solid Forms of Metformin Hydrochloride and Thiazide Diuretics

Synthesis, Characterization, and Intrinsic Dissolution Studies of Drug-Drug Eutectic Solid Forms of Metformin Hydrochloride and Thiazide Diuretics

The mechanochemical synthesis of drug-drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported. Characterization of these new systems indicates formation of binary eutectic conglomerates, i.e., drug-drug eutect...

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Main Authors: Guadalupe Coyote-Dotor (Author), José C. Páez-Franco (Author), Daniel Canseco-González (Author), Alejandra Núñez-Pineda (Author), Alejandro Dorazco-González (Author), Inés Fuentes-Noriega (Author), Alfredo R. Vilchis-Néstor (Author), Joelis Rodríguez-Hernández (Author), David Morales-Morales (Author), Juan Manuel Germán-Acacio (Author)
Format: Book
Published: MDPI AG, 2021-11-01T00:00:00Z.
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