Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice

• Main Authors: Yme U. van der Velden (Author), Julien Villaudy (Author), Esther Siteur - van Rijnstra (Author), Cynthia A. van der Linden (Author), Monique A. Vink (Author), Edith E. Schermer (Author), Kees Weijer (Author), Ben Berkhout (Author), Rogier W. Sanders (Author), Marit J. van Gils (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have shown the potential of broadly neutralizing antibodies (bnAbs) for HIV-1 treatment. One of the candidate antibodies moving into clinical trials is the bnAb PGDM1400. Here, we studied the therapeutic potency and escape pathways of bnAb PGDM1400 during monovalent therapy in human i...