Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds

SUMMARY Lipid droplet formation and subsequent steatosis (the abnormal retention of lipids within a cell) has been reported to contribute to hepatotoxicity and is an adverse effect of many pharmacological agents including the antiepileptic drug valproic acid (VPA). In this study, we have developed a...

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Main Authors: Lucy M. Elphick (Author), Nadine Pawolleck (Author), Irina A. Guschina (Author), Leila Chaieb (Author), Daniel Eikel (Author), Heinz Nau (Author), John L. Harwood (Author), Nick J. Plant (Author), Robin S. B. Williams (Author)
Format: Book
Published: The Company of Biologists, 2012-03-01T00:00:00Z.
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