Development of neoantigens: from identification in cancer cells to application in cancer vaccines

• Main Authors: Nasim Ebrahimi (Author), Maryam Akbari (Author), Masoud Ghanaatian (Author), Parichehr Roozbahani moghaddam (Author), Samaneh Adelian (Author), Marziyeh Borjian Boroujeni (Author), Elnaz Yazdani (Author), Amirhossein Ahmadi (Author), Michael R. Hamblin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTIntroduction The discovery of neoantigens as mutated proteins specifically expressed in tumor cells but not in normal cells has led to improved cancer vaccines. Targeting neoantigens can induce anti-tumor T-cell responses to destroy tumors without damaging healthy cells. Extensive advances i...