A phase I study comparing the pharmacokinetics and safety of HS628 (tocilizumab biosimilar) and reference tocilizumab in healthy male subjects

• Autori principali: Hongjie Qian (Autore), Jie Cheng (Autore), Yuzhou Gui (Autore), Wei Wang (Autore), Liyu Liang (Autore), Huijuan Zhu (Autore), Qingqing Wu (Autore), Meixian Ou (Autore), Qian Chen (Autore), Chen Yu (Autore), Jingying Jia (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2023-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract This study aimed to evaluate the pharmacokinetic (PK) similarity of the proposed biosimilar HS628 compared with the reference tocilizumab (Actemra®) and also to demonstrate similar safety and immunogenicity profiles in healthy Chinese male subjects. Eighty eligible subjects were randomized...