Switching Between LC-ESI-MS/MS and EMIT Methods for Routine TDM of Valproic Acid in Pediatric Patients With Epilepsy: What Clinicians and Researchers Need to Know

• Main Authors: Ying Xia (Author), Jia-Yi Long (Author), Meng-Yuan Shen (Author), Na Dong (Author), Hong-Li Guo (Author), Ya-Hui Hu (Author), Xiao-Peng Lu (Author), Xuan-Sheng Ding (Author), Feng Chen (Author), Jin-Chun Qiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Valproic acid (VPA) is a widely used antiseizure medication and its dosing needs to be tailored individually through therapeutic drug monitoring (TDM) to avoid or prevent toxicity. Currently, immune-enzymatic assays such as Enzyme Multiplied Immunoassay Technique (EMIT), and Liquid Chrom...