Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity

• Main Authors: Maximiliano Martínez-Cifuentes (Author), Emmanuel Soto-Tapia (Author), Camila Linares-Pipón (Author), Ben Bradshaw (Author), Paulina Valenzuela-Hormazabal (Author), David Ramírez (Author), Patricio Muñoz-Torres (Author), Claudio Parra (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work proposes the design of β-keto esters as antibacterial compounds. The design was based on the structure of the autoinducer of bacterial quorum sensing, <i>N</i>-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). Eight β-keto ester analogues were synthesised with good yields a...