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Improvement of Motor Nerve Conduction Velocity in Diabetic Rats Requires Normalization of the Polyol Pathway Metabolites Flux

Using ranirestat, an aldose reductase (AR) inhibitor, we investigated the relationship between sorbitol and fructose levels in the sciatic nerve and motor nerve conduction velocity (MNCV) in streptozotocin (STZ)-treated diabetic rats. Ranirestat inhibited rat and recombinant human AR with similar IC...

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Main Authors: Takafumi Matsumoto (Author), Yoshiyuki Ono (Author), Masuo Kurono (Author), Akemi Kuromiya (Author), Keiji Nakamura (Author), Vera Bril (Author)
Format: Book
Published: Elsevier, 2009-01-01T00:00:00Z.
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3rd Floor Main Library

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