A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs

• Main Authors: Anja Kolarič (Author), Maja Kokot (Author), Martina Hrast (Author), Matjaž Weiss (Author), Irena Zdovc (Author), Jurij Trontelj (Author), Simon Žakelj (Author), Marko Anderluh (Author), Nikola Minovski (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of antibacterial activity, even against some of the m...