5'-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

• Main Authors: Tingyu Zong (Author), Yanyan Yang (Author), Xiaotong Lin (Author), Shaoyan Jiang (Author), Hui Zhao (Author), Meixin Liu (Author), Yuanyuan Meng (Author), Yong Li (Author), Liang Zhao (Author), Guozhang Tang (Author), Kun Gong (Author), Zhibin Wang (Author), Tao Yu (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) are still unknown. In this study, we found that 5'-tiRNA-Cys-GCA was significantly downregulated in human and mouse models of aortic disse...