Discovering metabolic disease gene interactions by correlated effects on cellular morphology

• Main Authors: Yang Jiao (Author), Umer Ahmed (Author), M.F. Michelle Sim (Author), Andrea Bejar (Author), Xiaolan Zhang (Author), M. Mesbah Uddin Talukder (Author), Robert Rice (Author), Jason Flannick (Author), Anna I. Podgornaia (Author), Dermot F. Reilly (Author), Jesse M. Engreitz (Author), Maria Kost-Alimova (Author), Kate Hartland (Author), Josep-Maria Mercader (Author), Sara Georges (Author), Vilas Wagh (Author), Marija Tadin-Strapps (Author), John G. Doench (Author), J. Michael Edwardson (Author), Justin J. Rochford (Author), Evan D. Rosen (Author), Amit R. Majithia (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Impaired expansion of peripheral fat contributes to the pathogenesis of insulin resistance and Type 2 Diabetes (T2D). We aimed to identify novel disease-gene interactions during adipocyte differentiation. Methods: Genes in disease-associated loci for T2D, adiposity and insulin resistance...