Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension

• Main Authors: Beatriz eGálvez-Prieto (Author), Beatriz eSomoza (Author), Marta eGil-Ortega (Author), Concha eF García-Prieto (Author), Ana ede las Heras (Author), María eGonzález (Author), Silvia eArribas (Author), Isabel eAranguez (Author), Juliane eBolbrinker (Author), Reinhold eKreutz (Author), Mariano eRuiz-Gayo (Author), María S Fernández-Alfonso (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthetized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously rats (SHR) might contribute to a diminished paracrine ant...