The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism

• Main Authors: Feng Ye (Author), Jinhuan Ni (Author), Xinyue Li (Author), Jing Wang (Author), Jianchao Luo (Author), Shiyu Wang (Author), Xiaoyu Xu (Author), Yunshan Zhong (Author), Jianchang Qian (Author), Zhongxiang Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to clarify the drug interaction profile of aumolertinib, and the influence of CYP3A4 genetic polymorphism on aumolertinib metabolic characteristics. Through microsomal enzyme reactions, we screened 153 drugs and identified 15 that significantly inhibited the metabolism o...