Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel

• Main Authors: Chenling Xiong (Author), Katherina C. Chua (Author), Tore B. Stage (Author), Josefina Priotti (Author), Jeffrey Kim (Author), Anne Altman‐Merino (Author), Daniel Chan (Author), Krishna Saraf (Author), Amanda Canato Ferracini (Author), Faranak Fattahi (Author), Deanna L. Kroetz (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemotherapy‐induced peripheral neuropathy (CIPN) is a dose‐limiting adverse event associated with treatment with paclitaxel and other chemotherapeutic agents. The prevention and treatment of CIPN are limited by a lack of understanding of the molecular mechanisms underlying this toxicity. In the cur...