Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

• Main Authors: Sibylle Sabrautzki (Author), Gabriele Kaiser (Author), Gerhard K.H. Przemeck (Author), Felicia Gerst (Author), Estela Lorza-Gil (Author), Madhura Panse (Author), Tina Sartorius (Author), Miriam Hoene (Author), Susan Marschall (Author), Hans-Ulrich Häring (Author), Martin Hrabě de Angelis (Author), Susanne Ullrich (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glucose-induced insulin secretion (GIIS) in pancreatic β-cells. Genetically engineered Ffar1-knockout/congenic mice univocally displayed impaired fatty acid-mediated insulin secretion, but in vivo experi...