Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis.

• Main Authors: Rahajeng N Tunjungputri (Author), Muhammad Hussein Gasem (Author), Willemijn van der Does (Author), Pandu H Sasongko (Author), Bambang Isbandrio (Author), Rolf T Urbanus (Author), Philip G de Groot (Author), Andre van der Ven (Author), Quirijn de Mast (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe leptospirosis is frequently complicated by a hemorrhagic diathesis, of which the pathogenesis is still largely unknown. Thrombocytopenia is common, but often not to the degree that spontaneous bleeding is expected. We hypothesized that the hemorrhagic complications are not only related to thr...