GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior

• Main Authors: Fuka Aizawa (Author), Takashi Nishinaka (Author), Takuya Yamashita (Author), Kazuo Nakamoto (Author), Takashi Kurihara (Author), Akira Hirasawa (Author), Fumiyo Kasuya (Author), Atsuro Miyata (Author), Shogo Tokuyama (Author)
• Format: Book
• Published: Elsevier, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The free fatty acid receptor 1 (GPR40/FFAR1) is a G protein-coupled receptor, which is activated by long chain fatty acids. We have previously demonstrated that activation of brain GPR40/FFAR1 exerts an antinociceptive effect that is mediated by the modulation of the descending pain control system....