mTORC1 Signaling Pathway Mediates Chronic Stress-Induced Synapse Loss in the Hippocampus

• Main Authors: Yu-Fei Luo (Author), Xiao-Xia Ye (Author), Ying-Zhao Fang (Author), Meng-Die Li (Author), Zhi-Xuan Xia (Author), Jian-Min Liu (Author), Xiao-Shan Lin (Author), Zhen Huang (Author), Xiao-Qian Zhu (Author), Jun-Jie Huang (Author), Dong-Lin Tan (Author), Yu-Fei Zhang (Author), Hai-Ping Liu (Author), Jun Zhou (Author), Zu-Cheng Shen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The mechanistic target of rapamycin complex 1 (mTORC1) signaling has served as a promising target for therapeutic intervention of major depressive disorder (MDD), but the mTORC1 signaling underlying MDD has not been well elucidated. In the present study, we investigated whether mTORC1 si...