Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma

• Main Authors: Sebastian Lundgren (Author), Helena Fagerström-Vahman (Author), Cheng Zhang (Author), Liv Ben-Dror (Author), Adil Mardinoglu (Author), Mathias Uhlen (Author), Björn Nodin (Author), Karin Jirström (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract There is a great unmet clinical need to identify patients with thin primary cutaneous melanomas (T1, Breslow thickness ≤ 1 mm) who have a high risk for tumour recurrence and death from melanoma. Kin of IRRE-like protein 1 (KIRREL/NEPH1) is expressed in podocytes and involved in glomerular f...